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1

Reactions of α,β-Unsaturated Ketone Acetals with Trimethylsilyl Cyanide and Trimethylsilyl Sulfides

Soga, Tsunehiko, Takenoshita, Haruhiro, Yamada, Masaaki, Han, Jeng S., Mukaiyama, Teruaki

Journal:

Bulletin of the Chemical Society of Japan

Year:

1991

File:

PDF, 1.50 MB

1991

2

ChemInform Abstract: New Highly Active Taxoids from 9β-Dihydrobaccatin-9,10-acetals

Takashi Ishiyama, Shin Iimura, Satoru Ohsuki, Kouichi Uoto, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Year:

2002

File:

PDF, 30 KB

2002

3

New Highly Active Taxoids from 9β-Dihydrobaccatin-9,10-acetals. Part 2.

Takashi Ishiyama, Shin Iimura, Toshiharu Yoshino, Jun Chiba, Kouichi Uoto, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Year:

2003

File:

PDF, 96 KB

2003

4

A New Method for Synthesis of 7-Deoxytaxane Analogues by Hydrogenation of Δ6,7-Taxane Derivatives.

Yasuyuki Takeda, Toshiharu Yoshino, Kouichi Uoto, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Year:

2003

File:

PDF, 138 KB

2003

5

New Highly Active Taxoids from 9β-Dihydrobaccatin-9,10-acetals. Part 3.

Yasuyuki Takeda, Toshiharu Yoshino, Kouichi Uoto, Jun Chiba, Takashi Ishiyama, Michio Iwahana, Takeshi Jimbo, Noriko Tanaka, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Year:

2003

File:

PDF, 207 KB

2003

6

New Highly Active Taxoids from 9β-Dihydrobaccatin-9,10-acetals. Part 5

Yasuyuki Takeda, Kouichi Uoto, Michio Iwahana, Takeshi Jimbo, Motoko Nagata, Ryo Atsumi, Chiho Ono, Noriko Tanaka, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Year:

2004

File:

PDF, 18 KB

2004

7

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation, and structure–activity relationships

Takao Horiuchi, Jun Chiba, Kouichi Uoto, Tsunehiko Soga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 182 KB

english, 2009

8

Substrate selective inclusion by a series of water-soluble paracyclophanes — host-guest recognition of steric structure and charge —

Kazunori Odashima, Tsunehiko Soga, Kenji Koga

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 272 KB

english, 1981

9

Catalytic asymmetric synthesis of optically active β-amino acids

Kazuo Achiwa, Tsunehiko Soga

Journal:

Tetrahedron Letters

Year:

1978

Language:

english

File:

PDF, 130 KB

english, 1978

10

Orally active docetaxel analogue: synthesis of 10-deoxy-10-C-morpholinoethyl docetaxel analogues

Shin Iimura, Kouichi Uoto, Satoru Ohsuki, Jun Chiba, Toshiharu Yoshino, Michio Iwahana, Takeshi Jimbo, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 209 KB

english, 2001

11

New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 2

Takashi Ishiyama, Shin Iimura, Toshiharu Yoshino, Jun Chiba, Kouichi Uoto, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 172 KB

english, 2002

12

First synthesis and cytotoxic activity of novel docetaxel analogs modified at the C18-position

Kouichi Uoto, Ikuo Mitsui, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 247 KB

english, 1997

13

Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs

Kiyoshi Nakayama, Hirofumi Terasawa, Ikuo Mitsui, Satoru Ohsuki, Kouichi Uoto, Shin Iimura, Tsunehiko Soga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 284 KB

english, 1998

14

Significant antitumor effect of a synthetic lipid A analogue, DT-5461, on murine syngeneic tumor models

Eiji Kumazawa, Akiko Tohgo, Tsunehiko Soga, Tsuneo Kusama, Yasuaki Osada

Journal:

Cancer Immunology, Immunotherapy

Year:

1992

Language:

english

File:

PDF, 1.40 MB

english, 1992

15

New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 5

Yasuyuki Takeda, Kouichi Uoto, Michio Iwahana, Takeshi Jimbo, Motoko Nagata, Ryo Atsumi, Chiho Ono, Noriko Tanaka, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 323 KB

english, 2004

16

Modifications of hydrophobic cavity and their effects on the complex formation with a hydrophobic substrate

Tsunehiko Soga, Kazunori Odashima, Kenji Koga

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 253 KB

english, 1980

17

New highly active taxoids from 9β-Dihydrobaccatin-9,10-acetals

Takashi Ishiyama, Shin Iimura, Satoru Ohsuki, Kouichi Uoto, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

18

New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 3

Yasuyuki Takeda, Toshiharu Yoshino, Kouichi Uoto, Jun Chiba, Takashi Ishiyama, Michio Iwahana, Takeshi Jimbo, Noriko Tanaka, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 318 KB

english, 2003

19

New highly active taxoids from 9β-Dihydrobaccatin-9,10-acetals. Part 4

Yasuyuki Takeda, Kouichi Uoto, Jun Chiba, Takao Horiuchi, Michio Iwahana, Ryo Atsumi, Chiho Ono, Hirofumi Terasawa, Tsunehiko Soga

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 440 KB

english, 2003

20

DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo

Motoko Shionoya, Takeshi Jimbo, Mayumi Kitagawa, Tsunehiko Soga, Akiko Tohgo

Journal:

Year:

2003

Language:

english

File:

PDF, 199 KB

english, 2003

21

Discovery of novel dihydroimidazothiazole derivatives as p53–MDM2 protein–protein interaction inhibitors: Synthesis, biological evaluation and structure–activity relationships

Miyazaki, Masaki, Kawato, Haruko, Naito, Hiroyuki, Ikeda, Masahiro, Miyazaki, Masaya, Kitagawa, Mayumi, Seki, Takahiko, Fukutake, Setsuko, Aonuma, Masashi, Soga, Tsunehiko

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.28 MB

english, 2012

22

Symposium Reporter 2004

Miyazaki, Masaki, Kawato, Haruko, Naito, Hiroyuki, Ikeda, Masahiro, Miyazaki, Masaya, Kitagawa, Mayumi, Seki, Takahiko, Fukutake, Setsuko, Aonuma, Masashi, Soga, Tsunehiko

Journal:

Journal of the American Medical Directors Association

Year:

2004

Language:

english

File:

PDF, 49 KB

english, 2004

23

Efficient Activation of Acetals, Aldehydes, and Imines toward Silylated Nucleophiles by the Combined Use of Catalytic Amounts of [Rh(COD)Cl] 2 and TMS-CN under Almost Neutral Conditions

Soga, Tsunehiko, Takenoshita, Haruhiro, Yamada, Masaaki, Mukaiyama, Teruaki

Journal:

Bulletin of the Chemical Society of Japan

Year:

1990

File:

PDF, 1.63 MB

1990

24

Reactions of Acetals of α,β-Unsaturated Ketones with Silylated Nucleophiles as Trimethylsilyl Cyanide and Phenylthiotrimethylsilanes

Mukaiyama, Teruaki, Takenoshita, Haruhiro, Yamada, Masaaki, Soga, Tsunehiko

Journal:

Chemistry Letters

Year:

1990

File:

PDF, 341 KB

1990

25

Efficient Method for the Preparation of ( Z )-α-Alkoxy-β,γ-unsaturated Nitriles Starting from the Corresponding Acetals of ( E )-Chalcone Derivatives

Mukaiyama, Teruaki, Takenoshita, Haruhiro, Yamada, Masaaki, Soga, Tsunehiko

Journal:

Chemistry Letters

Year:

1990

File:

PDF, 171 KB

1990

26

Efficient Activation of Acetals toward Nucleophiles by the Use of Transition Metal Salts. New Method for Cyanation of Acetals and Orthoester Derived from Aromatic and α,β-Unsaturated Carbonyl Compounds with Trimethylsilyl Cyanide under Neutral Condition

Mukaiyama, Teruaki, Soga, Tsunehiko, Takenoshita, Haruhiro

Journal:

Chemistry Letters

Year:

1989

File:

PDF, 270 KB

1989

27

Efficient Activation of Acetals toward Nucleophiles with [Rh(COD)Cl] 2 Catalyst. New Method for the Preparation of Aldols from Acetals and Silyl Enol Ethers by the Combined Use of Catalytic Amounts of [Rh(COD)Cl] 2 and Trimethylsilyl Cyanide

Mukaiyama, Teruaki, Soga, Tsunehiko, Takenoshita, Haruhiro

Journal:

Chemistry Letters

Year:

1989

File:

PDF, 351 KB

1989

28

Synthesis and antitumor activity of lipid A analogs having a phosphonooxyethyl group with .ALPHA.- or .BETA.-configuration at position 1.

KUSAMA, Tsuneo, SOGA, Tsunehiko, SHIOYA, Emiko, NAKAYAMA, Kiyoshi, NAKAJIMA, Hiroto, OSADA, Yasuaki, ONO, Yoshiyuki, KUSUMOTO, Shoichi, SHIBA, Tetsuo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1990

File:

PDF, 1.18 MB

1990

29

Novel stereoselective glycosidation by the combined use of trityl halide and Lewis acid.

HIGASHI, Kunio, NAKAYAMA, Kiyoshi, SOGA, Tsunehiko, SHIOYA, Emiko, UOTO, Kouichi, KUSAMA, Tsuneo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1990

File:

PDF, 648 KB

1990

30

A Useful Method for Deprotection of the Protective Allyl Group at the Anomeric Oxygen of Carbohydrate Moieties Using Tetrakis(triphenylphosphine)palladium.

NAKAYAMA, Kiyoshi, UOTO, Kouichi, HIGASHI, Kunio, SOGA, Tsunehiko, KUSAMA, Tsuneo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1992

File:

PDF, 596 KB

1992

31

Synthesis and Biological Activities of Analogs of a Lipid A Biosynthetic Precursor: 1-O-Phosphonooxyethyl-4'-O-phosphono-disaccharides with (R)-3-Hydroxytetradecanoyl or Tetradecanoyl Groups at Positions 2, 3, 2' and 3'.

KUSAMA, Tsuneo, SOGA, Tsunehiko, ONO, Yoshiyuki, KUMAZAWA, Eiji, SHIOYA, Emiko, OSADA, Yasuaki, KUSUMOTO, Shoichi, SHIBA, Tetsuo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1991

File:

PDF, 986 KB

1991

32

Synthesis and Biological Activities of Lipid A Analogs: Modification of a Glycosidically Bound Group with Chemically Stable Polar Acidic Groups and Lipophilic Groups on the Disaccharide Backbone with Tetradecanoyl of N-Dodecanoylglycyl Groups.

KUSAMA, Tsuneo, SOGA, Tsunehiko, ONO, Yashiyuki, KUMAZAWA, Eiji, SHIOYA, Emiko, NAKAYAMA, Kiyoshi, Kouichi, UOTO, OSADA, Yasuaki

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1991

File:

PDF, 1.57 MB

1991

33

Zinc Triflate-Promoted Glycosidation: Synthesis of Lipid A Disaccharide Intermediates.

NAKAYAMA, Kiyoshi, HIGASHI, Kunio, SOGA, Tsunehiko, UOTO, Kouichi, KUSAMA, Tsuneo

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1992

File:

PDF, 817 KB

1992

34

A New Method to Modify the C-4 Position of 10-Deacetylbaccatin III.

UOTO, Kouichi, TAKENOSHITA, Haruhiro, ISHIYAMA, Takashi, TERASAWA, Hirofumi, SOGA, Tsunehiko

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1997

File:

PDF, 548 KB

1997

35

Synthesis and Structure-Activity Relationships of Novel 2',2'-Difluoro Analogues of Docetaxel.

UOTO, Kouichi, OHSUKI, Satoru, TAKENOSHITA, Haruhiro, ISHIYAMA, Takashi, IIMURA, Shin, HIROTA, Yasuhide, MITSUI, Ikuo, TERASAWA, Hirofumi, SOGA, Tsunehiko

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1997

File:

PDF, 1.72 MB

1997

36

A New Method for Synthesis of 7-Deoxytaxane Analogues by Hydrogenation of Δ6,7-Taxane Derivatives

Takeda, Yasuyuki, Yoshino, Toshiharu, Uoto, Kouichi, Terasawa, Hirofumi, Soga, Tsunehiko

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2002

Language:

english

File:

PDF, 70 KB

english, 2002

37

Semisynthetic .BETA.-lactam antibiotics. III Synthesis and antibacterial activity of 7.BETA.-(2-(2-aminothiazol-4-yl)-2-(substituted carbamoylmethoxyimino)acetamido)cephalosporins.

ARIMOTO, MASAHIRO, HAYANO, TAKESHI, SOGA, TSUNEHIKO, YOSHIOKA, TOSHIYUKI, TAGAWA, HIROAKI, FURUKAWA, MINORU

Journal:

The Journal of Antibiotics

Year:

1986

Language:

english

File:

PDF, 6.13 MB

english, 1986

38

Synthesis and antibacterial activity of new 2-substituted penems. II.

NISHI, TOSHIYUKI, HIGASHI, KUNIO, SOGA, TSUNEHIKO, TAKEMURA, MAKOTO, SATO, MAKOTO

Journal:

The Journal of Antibiotics

Year:

1994

Language:

english

File:

PDF, 831 KB

english, 1994

39

Synthesis and Evaluation of Water-Soluble Non-Prodrug Analogs of Docetaxel Bearing sec-Aminoethyl Group at the C-10 Position.

UOTO, Kouichi, TAKENOSHITA, Haruhiro, YOSHINO, Toshiharu, HIROTA, Yasuhide, ANDO, Shuichi, MITSUI, Ikuo, TERASAWA, Hirofumi, SOGA, Tsunehiko

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1998

File:

PDF, 1.10 MB

1998

40

Synthesis and Antitumor Activity of Non-Prodrug Water-soluble Taxoid: 10-C-Aminoalkylated Docetaxel Analogs

Iimura, Shin, Ohsuki, Satoru, Chiba, Jun, Uoto, Kouichi, Iwahana, Michio, Terasawa, Hirofumi, Soga, Tsunehiko

Journal:

Year:

2000

Language:

english

File:

PDF, 125 KB

english, 2000